Science inevitably butts up against limitations in human sensory apparatus and cognition overall. There is just so far we can peer out into the cosmos or down into subatomic particles, and there is just so much we can absorb about what we're seeing.
Then, there is the biggest limitation of all. Science is utterly ill-equipped to deal with existential questions. It can explain what is going on in the world around us. It can't explain why we're here.
Carl Remick