Better living through chemistry

Carl Remick carlremick at hotmail.com
Thu Jan 11 14:26:17 PST 2001


[From this week's New Scientist]

Killer virus

An engineered mouse virus leaves us one step away from the ultimate bioweapon

A virus that kills every one of its victims, by wiping out part of their immune system, has been accidentally created by an Australian research team. The virus, a modified mousepox, does not affect humans, but it is closely related to smallpox, raising fears that the technology could be used in biowarfare.

The discovery highlights a growing problem. How do you stop terrorists taking legitimate research and adapting it for their own nefarious purposes?

The Australian researchers had no intention of producing a killer virus. They were merely trying to make a mouse contraceptive vaccine for pest control. "But it's a good way to show how to alter smallpox to make it more virulent," says Ken Alibek, former second-in-command of the civilian branch of the Soviet germ-warfare programme....

To make matters worse, the engineered virus also appears unnaturally resistant to attempts to vaccinate the mice. A vaccine that would normally protect mouse strains that are susceptible to the virus only worked in half the mice exposed to the killer version. "It's surprising how very, very bad the virus is," says Ann Hill, a vaccine researcher from Oregon Health Sciences University in Portland. If bioterrorists created a human version of the virus, vaccination programmes would be of limited use.

[Full text: http://www.newscientist.com/dailynews/news.jsp?id=ns9999311]

Carl

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