Singapore nets US cancer experts in biomedics drive
Tue Jan 10, 2006
By Sara Webb and Mia Shanley
SINGAPORE (Reuters) - When top U.S. scientists Neal Copeland and Nancy Jenkins arrive in Singapore to set up a new cancer research project, they will bring some extraordinary luggage: thousands and thousands of mice.
The husband-and-wife team will bring 50 to 100 different strains of mice for their research into the most common types of human cancer when they move to the city-state in coming weeks.
Their decision to relocate to Singapore -- which they chose over leading U.S. cancer research centers at New York's Memorial Sloan-Kettering and California's Stanford University -- is a coup for Singapore, where the government is spending billions of dollars to develop its biomedical industry.
"They are a big catch. They are prominent researchers, very successful in the U.S.," said Alan Colman, the British scientist whose team cloned Dolly, the world's most famous sheep.
Colman himself is one of a cluster of star scientists that Singapore has lured in a bid to put the city-state of 4.4 million people on the map for biomedical research and drugs production.
Scientists in the United States now face restrictions on government funding for stem cell research, shriveling grants, and curbs on commercial spin-offs from their work such as consulting and other fees, Copeland and Jenkins told Reuters in a telephone interview ahead of their departure for Singapore.
"The amount of money going toward research is going down. It doesn't have a high priority (in the United States). In Singapore it does," said Copeland, adding that they would like to exploit some of their Singapore-funded research commercially.
Copeland and Jenkins said they had been won over by Singapore's scientific freedom, deep pockets and interest in commercial applications, at a time when the U.S. government's National Cancer Institute in Maryland -- where they worked for 20 years -- began a clamp-down on consulting work by its scientists.
"This is a chance to explore new areas," said Jenkins.
OF MICE AND MEN
Copeland, 58, and Jenkins, 55, use the mouse genome to study which genes trigger cancers in humans.
"We use mouse genetics as a tool for human diseases," Copeland said, adding that their research tries to identify the genes and develop the drugs to fight the most common cancers.
Copeland and Jenkins met 25 years ago as researchers at Harvard Medical School, and have worked together for more than 20 years, co-authoring over 700 research papers.
Their most recent work employs a technique known as "sleeping beauty" because of the way that it uses inactive genetic material to activate or awaken cancer genes.
That work could lead to a better understanding of the series of steps that take place when a person develops cancer, said David Lane, who heads the Institute of Molecular and Cell Biology in Singapore where Copeland and Jenkins will work.
Lane, who discovered the important "p53" cancer gene which suppresses tumors and whose work in Singapore focuses on zebra fish, said that with the arrival of Copeland and Jenkins, Singapore is starting to attract more interest in the scientific community as it has built up a critical mass of superstars.
"People will go to where the big names are," Lane said. "The challenge is to create a place where people want to come."
Philip Yeo, head of Singapore's Economic Development Board, makes no secret of the fact he wants to attract "whales" -- or scientists with an international reputation.
In addition to Colman, Singapore has attracted Sydney Brenner, co-winner of the 2002 Nobel prize in Physiology or Medicine for work on the genetic regulation of organ development.
Others include breast cancer researcher Edison Liu, who was born in Hong Kong and emigrated to the United States, and Japan's Yoshiaki Ito. Both had worked at the National Cancer Institute, and Ito was instrumental in enticing Copeland and Jenkins to Singapore.
MONEY AND ETHICS
In an era where funding is critical -- even a microscope can cost half a million dollars -- wealthy Singapore has the money.
That, say scientists, has been Singapore's attraction, along with speedy grant approvals and lack of burdensome paperwork.
"We don't want to spend the rest of our lives writing grants," said Copeland, adding that Singapore's quick access to funding was key. The couple's colony of 20,000 mice costs some $1 million a year to maintain.
Scientific research today is increasingly about access to grants and rewards such as fame, prizes and commercial spin-offs -- incentives which can sometimes lead to unethical practices, as South Korea's stem cell research scandal has shown.
But Copeland and Jenkins, who hope to be based in Singapore for the long run, say the fall-out will have no impact on Singapore's ambitions to become Asia's leading biomedical center.
Lane says Singapore already has a pile of applicants.
"You suddenly cross some threshold, where instead of scouring the world trying to get people to come here, you are suddenly in a position" to pick and choose, Lane said.
© Reuters 2006. All Rights Reserved.